Evaluation of iron oxide nanoparticle biocompatibility
Identifieur interne : 000488 ( Main/Exploration ); précédent : 000487; suivant : 000489Evaluation of iron oxide nanoparticle biocompatibility
Auteurs : Amel Hanini [France, Tunisie] ; Alain Schmitt [France] ; Kamel Kacem [Tunisie] ; François Chau [France] ; Souad Ammar [France] ; Julie Gavard [France]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2011.
Abstract
Nanotechnology is an exciting field of investigation for the development of new treatments for many human diseases. However, it is necessary to assess the biocompatibility of nanoparticles in vitro and in vivo before considering clinical applications. Our characterization of polyol-produced maghemite γ-Fe2O3 nanoparticles showed high structural quality. The particles showed a homogeneous spherical size around 10 nm and could form aggregates depending on the dispersion conditions. Such nanoparticles were efficiently taken up in vitro by human endothelial cells, which represent the first biological barrier to nanoparticles in vivo. However, γ-Fe2O3 can cause cell death within 24 hours of exposure, most likely through oxidative stress. Further in vivo exploration suggests that although γ-Fe2O3 nanoparticles are rapidly cleared through the urine, they can lead to toxicity in the liver, kidneys and lungs, while the brain and heart remain unaffected. In conclusion, γ-Fe2O3 could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications.
Url:
DOI: 10.2147/IJN.S17574
PubMed: 21589646
PubMed Central: 3090275
Affiliations:
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Descartes, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nanotechnology is an exciting field of investigation for the development of new treatments for many human diseases. However, it is necessary to assess the biocompatibility of nanoparticles in vitro and in vivo before considering clinical applications. Our characterization of polyol-produced maghemite γ-Fe<sub>2</sub>O<sub>3</sub> nanoparticles showed high structural quality. The particles showed a homogeneous spherical size around 10 nm and could form aggregates depending on the dispersion conditions. Such nanoparticles were efficiently taken up in vitro by human endothelial cells, which represent the first biological barrier to nanoparticles in vivo. However, γ-Fe<sub>2</sub>O<sub>3</sub> can cause cell death within 24 hours of exposure, most likely through oxidative stress. Further in vivo exploration suggests that although γ-Fe<sub>2</sub>O<sub>3</sub> nanoparticles are rapidly cleared through the urine, they can lead to toxicity in the liver, kidneys and lungs, while the brain and heart remain unaffected. In conclusion, γ-Fe<sub>2</sub>O<sub>3</sub> could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Maynard, Ad" uniqKey="Maynard A">AD Maynard</name></author><author><name sortKey="Aitken, Rj" uniqKey="Aitken R">RJ Aitken</name></author><author><name sortKey="Butz, T" uniqKey="Butz T">T Butz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lanone, S" uniqKey="Lanone S">S Lanone</name></author><author><name sortKey="Boczkowski, J" uniqKey="Boczkowski J">J Boczkowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, Jb" uniqKey="Hall J">JB Hall</name></author><author><name sortKey="Dobrovolskaia, Ma" uniqKey="Dobrovolskaia M">MA Dobrovolskaia</name></author><author><name sortKey="Patri, Ak" 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Z">Z Beji</name></author><author><name sortKey="Hanini, A" uniqKey="Hanini A">A Hanini</name></author><author><name sortKey="Smiri, Ls" uniqKey="Smiri L">LS Smiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, M" uniqKey="Ding M">M Ding</name></author><author><name sortKey="Kisin, Er" uniqKey="Kisin E">ER Kisin</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cornell, Rm" uniqKey="Cornell R">RM Cornell</name></author><author><name sortKey="Schwertmann, U" uniqKey="Schwertmann U">U Schwertmann</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Tunisie</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Hanini, Amel" sort="Hanini, Amel" uniqKey="Hanini A" first="Amel" last="Hanini">Amel Hanini</name></region><name sortKey="Ammar, Souad" sort="Ammar, Souad" uniqKey="Ammar S" first="Souad" last="Ammar">Souad Ammar</name><name sortKey="Ammar, Souad" sort="Ammar, Souad" uniqKey="Ammar S" first="Souad" last="Ammar">Souad Ammar</name><name sortKey="Chau, Francois" sort="Chau, Francois" uniqKey="Chau F" first="François" last="Chau">François Chau</name><name sortKey="Chau, Francois" sort="Chau, Francois" uniqKey="Chau F" first="François" last="Chau">François Chau</name><name sortKey="Gavard, Julie" sort="Gavard, Julie" uniqKey="Gavard J" first="Julie" last="Gavard">Julie Gavard</name><name sortKey="Gavard, Julie" sort="Gavard, Julie" uniqKey="Gavard J" first="Julie" last="Gavard">Julie Gavard</name><name sortKey="Gavard, Julie" sort="Gavard, Julie" uniqKey="Gavard J" first="Julie" last="Gavard">Julie Gavard</name><name sortKey="Hanini, Amel" sort="Hanini, Amel" uniqKey="Hanini A" first="Amel" last="Hanini">Amel Hanini</name><name sortKey="Hanini, Amel" sort="Hanini, Amel" uniqKey="Hanini A" first="Amel" last="Hanini">Amel Hanini</name><name sortKey="Hanini, Amel" sort="Hanini, Amel" uniqKey="Hanini A" first="Amel" last="Hanini">Amel Hanini</name><name sortKey="Schmitt, Alain" sort="Schmitt, Alain" uniqKey="Schmitt A" first="Alain" last="Schmitt">Alain Schmitt</name><name sortKey="Schmitt, Alain" sort="Schmitt, Alain" uniqKey="Schmitt A" first="Alain" last="Schmitt">Alain Schmitt</name><name sortKey="Schmitt, Alain" sort="Schmitt, Alain" uniqKey="Schmitt A" first="Alain" last="Schmitt">Alain Schmitt</name></country><country name="Tunisie"><noRegion><name sortKey="Hanini, Amel" sort="Hanini, Amel" uniqKey="Hanini A" first="Amel" last="Hanini">Amel Hanini</name></noRegion><name sortKey="Kacem, Kamel" sort="Kacem, Kamel" uniqKey="Kacem K" first="Kamel" last="Kacem">Kamel Kacem</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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